A reader sent me a question the other day: what font to use in Excel instead of the boring and over-used Calibri/Arial?
I think there is not much to gain from using custom fonts in Excel. Readability is requirement number one, and the standard ones deliver. Moreover, Excel sheets are often emailed around to multiple people, and changing fonts creates compatibility issues.
The biggest opportunity to make Excel sheets look better is in the layout of your worksheets and typography. Subtle use of bold, carefully selecting the language you use, grouping similar items together, subtle grey box fills, etc. With a few little adjustments you can make your Excel sheet look like a nicely formated page out of an annual report.