Last week in New York, I used both Keynote and Adobe Acrobat for the first time on stage in a live presentation. Keynote worked great (it is designed to do just that). Presenting in Adobe Acrobat (PDF) was interesting.
I presented at a large conference (this one) where it is hard to switch hardware (I needed a Mac for Keynote) in the middle of the conference program without disrupting the experience of the audience (engineers walking back and forth, screens going on and off). Hence, I went for a PDF version of the deck. (An earlier post on why I think we are going to use PDF for presentations more and more)
With CMD-L you can put Adobe Acrobat in full screen mode, and it responds perfectly fine to the Logitech remote control I am using. The only adjustment you have to make is to make sure that any animated slide builds are spread out over multiple pages.
The one thing I am missing though is the ability to have presenter view in Adobe Acrobat: having a pre-view of the next slide displayed on the monitor that only the presenter can see. Adobe, are you listening? (An old post about PowerPoint presenter view)
To take this a bit further. The one thing that Apple can do to increase the penetration of Keynote is to develop a Windows application that can run Keynote presentations with animations. Editing is not necessary.