I stumbled on this recent (June 2008) video of Tim Lee, a comedian who uses PowerPoint extensively.
This was the first time that I saw a “PowerPoint-based comedian”. It looks like he is actually only starting to use all possible creative opportunities. At the moment, there are just (poorly formated) bars with made up statistics. There must be more possibilities here for someone with the combined PowerPoint (animations, images, colors, etc. etc.) and comedy talents. Unfortunately, I lack the latter… An archive of other PowerPoint comedy videos at Presentation Zen.